Consiglio Nazionale delle Ricerche
Consiglio Nazionale delle Ricerche
Institute of Clinical Physiology (IFC-CNR)
Via Moruzzi n. 1
56124 Pisa, Italy
Dr. Patricia Iozzo
MD, PhD, Head of Endrocrinology-Metabolism
& Nuclear Medicine
The group focuses on integrating in vivo imaging markers with molecular mechanisms/targets to characterize organ-specific metabolism and cardiovascular function in non-clinical models and in humans, in relation with the pathogenesis and complications of obesity, diabetes, and insulin resistance. Emphasis is given to the early developmental causes and biomarkers of disease and ageing, and to the neurobiology of food intake in relation with mental well-being as a determinant of eating habits and body weight control.
Dr. Maria Angela Guzzardi
PhD, clinical study, molecular mechanism
Dr. Tiziana Liistro
MSc, PhD student, PET imaging study
Dr. Elena Sanguinetti
MSc, PhD student, histological examinations
Dr. Letizia Guiducci
PhD, PET imaging study
Dr. Maria Grazia Andreassi
MSc, PhD, Head of Genetic Unit
She is responsible for the tasks related to mtDNA damage and epigenetic research activities.
The genetic research unit led by Dr. Maria Grazia Andreassi has extensive experience in molecular and genetic studies of cardiovascular diseases, including the understanding on how genes interact with environmental risk factors to cause disease.
Over the past decade, a key strand of of the Unit's work has been the hypothesis that oxidative-stress-induced DNA damage play an important role in the pathogenesis of atherosclerosis, influencing key physiological processes such as vascular senescence and apoptosis. The Unit will be responsible for the research activities related to the evaluation of mtDNA common deletion (mtDNA4977) and promoter methylation status of cell cycle regulatory genes (p16INK4A, p53, p21/Waf1/Cip1).
Clinical and Experimental Echo Unit
Dr. Rosa Sicari
MD, PhD, Head of clinical and experimental echo unit
The main interest of the group is in the field of non-invasive assessment of cardiovascular diseases, which are dealt with a multi-technology approach with ultrasound. From large and multicenter clinical trials addressing the prognostic impact of stress echocardiography, to the development of quantitative tools for the assessment of new imaging biomarkers to experimental ultrasound in vivo and in vitro.
Key participants: Rosa Sicari, MD. PhD, is Senior staff investigator of the Institute of Clinical Physiology, National Research Council; Chief of the Echocardiography Laboratory of the Institute of Clinical Physiology. Co-editor of the Biomed central Journal on-line Cardiovascular Ultrasound; Associate Editor of the European Heart Journal Cardiovascular Imaging; Chair of the Scientific Committee of the European Association of Echocardiography. Co-author of 130 articles on international peer reviewed journals (global impact factor >500).
Dr. Luna Gargani
Luna Gargani is a cardiologist, interested in ultrasound, particularly echocardiography and lung ultrasound. She is member of the Scientific Initiatives Committee and of the Certification/Accreditation Committee of the European Association of Echocardiography.
She is also member of the Expert Panel of the International Consensus Conference on lung ultrasound, and co-author of the first International evidence-based recommendations for point-of-care lung ultrasound.
International Project Management Office
Dr. Michela Rial
Research advisor, project manager
Dr. Chiara Benvenuti
The Institute of Clinical Physiology (IFC-CNR) is mostly dedicated to the study of cardiovascular and metabolic disorders, with growing interest in the pathophysiology and prevention of ageing. The Institute is highly multidisciplinary and has special expertise in the field of imaging, encompassing metabolic, molecular, anatomic and functional imaging with positron emission tomography, cardiovascular ultrasound, computed tomography, magnetic resonance and spectroscopy. The PET/Radiopharmacy Centre is equipped with a Cyclotron and GMP-certified 18F-FDG production, PET and µPET-µCT scanners. State-of-the-art ultrasound technology is available, including a recently acquired µUS scanner. The IFC owns fully equipped research facilities for in vivo studies and laboratories involved in genetics, proteomics, and systems biology. The IFC is currently involved in 27 EU-funded projects and a number of other International and National projects funded by the European Foundation for the Study of Diabetes and by the Italian Ministries of Health and Education, the Tuscany Region, Telethon and other sources.TOP